Burch and Goodwin (1984) conducted a field trial in UK to investigate the efficacy in vivo of Denagard® injectable, administered to pigs clinically affected with arthritis caused by M. hyosynoviae.
The affected pigs were injected intramuscularly with Denagard at 10 or 15 mg tiamulin hydrogen fumarate (thf)/kg bodyweight daily for three consecutive days (days 0, 1 and 2).
Assessment was made by a comparison of the weight gains and reduction in lameness scores over a 7 day period. An untreated negative control group was maintained for comparison purposes. The results obtained are summarized below.
Average weight gain results - Denagard® (tiamulin) injectable against M. hyosynoviae
Average weight gain results
Treatment group
No. of pigs
Av. wt
day 0 (kg)
Av. wt
day 3 (kg)
Difference day 0-3 (kg)
Av. wt
day 7 (kg)
Difference day 0-7 (kg)
Untreated controls
10
62
62.18
0.18
63.59
1.59
Denagard 10 mg thf
/kg body weight
9*
77.52
74.41
1.89**
77.45
4.93**
Denagard 15 mg thf
/kg body weight
10
63.41
64.59
1.18*
67.28
3.87**
1 pig removed from trial due to a fractured femur
** statistically significant P<0.01
* statistically significant P<0.02
Both Denagard injectable treated groups showed highly significant weight gain improvements (days 0-7) when compared to the unmedicated controls.
Average lameness scores - Denagard® (tiamulin) injectable against M. hyosynoviae
